Dehydro-flavonolignans from silymarin are potent inhibitors of lipid peroxidation in isolated respiring rat heart and liver mitochondria
نویسندگان
چکیده
منابع مشابه
Thenoyltrifluoracetone induces lipid peroxidation in rat liver mitochondria.
Addition of thenoyltrifluoracetone to mitochondria oxidizing NAD-dependent substrates induced lipid peroxidation and uncoupling of oxidative phosphorylation. Butylated hydroxytoluene, an antioxidant, prevented accumulation of lipid peroxidation products but failed to prevent deenergization of the mitochondria.
متن کاملThe Effect of Resveratrol against Acrolein Toxicity in Mitochondria isolated from Rat Liver
Introduction: Acrolein is an important environmental, food and water pollutant that plays an important role in the development of several diseases. Resveratrol is a phenolic compound with antioxidant properties found in fruits such as grapes, berries and peanuts. The purpose of this study was to evaluate the protective effect of resveratrol in preventing Acrolein-induced toxicity in isolated mi...
متن کاملIdentification of hepatoprotective flavonolignans from silymarin.
Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute to its hepatoprotective effects. In the current study, we evaluated the hepatoprotective actions of the seven major flavonolignans and one flavonoid that comprise silymarin. Activities tested included inhibition ...
متن کاملRole of Fructose as a Potent Antiarrhythmic and Anti-infarct agent in Isolated Rat Heart
In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...
متن کاملSilymarin, Natural Flavonolignans from Milk Thistle
Plants are a valuable source of pharmaceuticals, food ingredients, agrochemicals, insecticides, flavors and pigments. These compounds are called secondary metabolites. These are compounds with a restricted occurrence in taxonomic groups that are not essential for an organism to live but play a role in the interaction of the organism with its environment, ensuring the survival of the organism in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2014
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2014.05.240